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# Publications

118. Ham L, Coomer M, Öcal K, Grima R and Stumpf MPJ. 2023. The timing of cellular events: a stochastic vs deterministic perspective (submitted) PDF

117. Szavits-Nossan, J and Grima R. 2023. Charting the landscape of stochastic gene expression models using queueing theory (submitted) PDF

116. Cao Z, Chen R, Xu L, Zhou X, Fu X, Zhong W and Grima R. 2023. Efficient and scalable prediction of spatio-temporal stochastic gene expression in cells and tissues using graph neural networks (submitted) PDF

115. Wang Y, Yu Z, Grima R and Cao Z. 2023. Exact solution of a three-stage model of stochastic gene expression including cell-cycle dynamics (submitted) PDF

114. Kerr L, Grima R and Sproul D. 2023. Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin (to appear in PLOS Genetics) PDF

113. Grima R and Esmenjaud PM. 2023. Quantifying and correcting bias in transcriptional parameter inference from single-cell data (submitted) PDF

112. Szavits-Nossan, J and Grima R. 2023. Uncovering the effect of RNA polymerase steric interactions on gene expression noise: analytical distributions of nascent and mature RNA numbers, Physical Review E 108, 034405 (2023) PDF

111. Weidemann D, Singh A, Grima R and Hauf S. 2023. The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian. Science Advances 9.32: eadh5138 PDF

110. Öcal K, Sanguinetti G and Grima R. 2023. Model Reduction for the Chemical Master Equation: an Information-Theoretic Approach. Journal of Chemical Physics, 10.1063/5.0131445 PDF

109. Szavits-Nossan, J and Grima R. 2023. Steady-state distributions of nascent RNA for general initiation mechanisms. Physical Review Research 5, 013064 PDF

108. Jia C and Grima R. 2023. Coupling gene expression dynamics to cell size dynamics and cell cycle events: exact and approximate solutions of the extended telegraph model. iScience 26: 105746 PDF

107. Garcia-Tejera R, Schumacher L and Grima R. 2022. Regulation of stem cell dynamics through volume exclusion. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 478, 20220376 PDF

106. Fu X, Patel H, Coppola S, Xu L, Cao Z, Lenstra TL and Grima R. 2022. Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions. *eLife* 11:e82493 PDF

105. Jia C, Singh A and Grima R. 2022. Concentration fluctuations in growing and dividing cells: insights into the emergence of concentration homeostasis. PLoS Computational Biology 18(10): e1010574 PDF

104. Saint-Antoine M, Grima R. and Singh A. 2022. A fluctuation-based approach to infer kinetics and topology of cell-state switching (accepted for publication in the Proceedings of the 61st IEEE Conference on Decision and Control) PDF

103. Sukys A, Öcal K and Grima R. 2022. Approximating Solutions of the Chemical Master Equation using Neural Networks. iScience 25, 105010 PDF

102. Braichencko S, Grima R and Sanguinetti G. 2022. Bayesian learning of effective chemical master equations in crowded intracellular conditions, In: Petre, I., Păun, A. (eds) Computational Methods in Systems Biology. CMSB 2022. Lecture Notes in Computer Science, vol 13447. Springer, Cham. https://doi.org/10.1007/978-3-031-15034-0_12. PDF

101. Fu X, Zhou X, Gu D, Cao Z, Grima R. 2022. DelaySSAToolkit.jl: stochastic simulation of reaction systems with time delays in Julia. Bioinformatics doi:10.1093/bioinformatics/btac472 PDF

100. Öcal K, Gutmann MU, Sanguinetti G, Grima R. 2022. Inference and Uncertainty Quantification of Stochastic Gene Expression via Synthetic Models. Journal of the Royal Society Interface 19: 20220153 PDF

99. Filatova T, Popovic N and Grima R. 2022. Modulation of nuclear and cytoplasmic mRNA fluctuations by time-dependent stimuli: analytical distributions. Mathematical Biosciences 347, 108828 PDF

98. Kerr L, Sproul D and Grima R. 2022. Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns. J. Roy. Soc. Interface 19, 20210707 PDF

97. Jia C, Singh A and Grima R. 2022. Characterizing non-exponential growth and bimodal cell size distributions in fission yeast: an analytical approach. PLoS Computational Biology 18, e1009793 PDF

96. Szavits-Nossan, J and Grima R. 2022. Mean-field theory accurately captures the variation of copy number distributions across the mRNA's life cycle. Physical Review E 105, 014410. PDF

95. Braichenko S, Holehouse J. and Grima R. 2021. Distinguishing between models of mammalian gene expression: telegraph-like models versus mechanistic models. J. Roy. Soc. Interface 18, 20210510 PDF

94. Sukys A and Grima R. 2021. MomentClosure.jl: automated moment closure approximations in Julia. Bioinformatics 38, 289 PDF

93. Qingchao J, Fu X, Yan S, Li R, Du W, Cao Z, Qian F and Grima R. 2021. Neural network aided approximation and parameter inference of stochastic models of gene expression. Nature Communications 12, 2618 PDF

92. Jia C, and Grima R. 2021. Frequency domain analysis of fluctuations of mRNA and protein copy numbers within a cell lineage: theory and experimental validation. Physical Review X 11, 021032 PDF

91. Jia C, Singh A and Grima R. 2021. Cell size distribution of lineage data: analytic results and parameter inference. iScience 24, 102220 PDF

90. Filatova T, Popovic N and Grima R. 2021. Statistics of nascent and mature RNA fluctuations in a stochastic model of transcriptional initiation, elongation, pausing and termination. Bull. Math. Biol. 83, 3 PDF

89. Holehouse J, Sukys A and Grima R. 2020. Stochastic time-dependent enzyme kinetics: closed-form solution and transient bimodality. J. Chem. Phys. 153, 164113 PDF

88. Cao Z, Filatova T, Oyarzun D and Grima R. 2020. A stochastic model of gene expression with polymerase recruitment and pause release. Biophysical Journal 119, 1002-1014 PDF

87. Holehouse J, Gupta A, and Grima R. 2020. Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation. Journal of Physics A: Mathematical and Theoretical 53, 405601 PDF

86. Perez-Carrasco R, Beentjes CHL, and Grima R. 2020. Effects of cell cycle variability on lineage and population measurements of mRNA abundance. J. R. Interface 17:20200360 PDF

85. Jia C, and Grima R. 2020. Dynamical phase diagram of an auto-regulating gene in fast switching conditions. J. Chem. Phys. 152:174110 PDF

84. Jia C, and Grima R. 2020. Small protein number effects in stochastic models of autoregulated bursty gene expression. Journal of Chemical Physics 152:084115 PDF

83. Beentjes CHL, Perez-Carrasco R, and Grima R. 2020. Exact solution of stochastic gene expression models with bursting, cell cycle and replication dynamics. Physical Review E 101:032403 PDF

82. Holehouse J, Cao Z, and Grima R. 2020. Stochastic modeling of auto-regulatory genetic feedback loops: a review and comparative study. Biophysical Journal 118, 1517-1525 PDF

81. Cao Z and Grima R. 2020. Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells. Proceedings of the National Academy of Sciences of the United States of America 117, 4682-4692 PDF

80. Öcal K, Grima R and Sanguinetti G. 2019. Parameter estimation for biochemical reaction networks using Wasserstein distances. Journal of Physics A: Mathematical and Theoretical 53, 034002 PDF

79. Holehouse J and Grima R. 2019. Revisiting the reduction of stochastic models of genetic feedback loops under fast promoter switching conditions. Biophysical Journal 117, 1311-1330 PDF

78. Keizer EM, Bastian B, Smith RW, Grima R and Fleck C. 2019. Extending the linear-noise approximation to biochemical systems influenced by intrinsic noise and lognormal distributed extrinsic noise. Physical Review E 99:052417 PDF

77. Cao Z and Grima R. 2019. Accuracy of parameter estimation for auto-regulatory transcriptional feedback loops from noisy data. Journal of the Royal Society Interface 16: 20180967 PDF

76. Smith S and Grima R. 2018. Plasticity of the truth table of low-leakage genetic logic gates. Physical Review E 98:062410 PDF

75. Moraki E, Grima R and Painter K. 2018. A stochastic model of corneal epithelium maintenance with applications to wound healing. Journal of Mathematical Biology https://doi.org/10.1007/s00285-018-1308-9 PDF

74. Cao Z and Grima R. 2018. Linear mapping approximation of gene regulatory networks with stochastic dynamics. Nature Communications 9:3305 PDF

73. Smith S and Grima R. 2018. Spatial stochastic intracellular kinetics - a review of modelling approaches. Bulletin of Mathematical Biology https://doi.org/10.1007/s11538-018-0443-1 PDF

72. Grima R, Sonntag S, Venezia F, Smith RW, Kircher S and Fleck C. 2018. Insight into nuclear body formation of phytochromes through theory and experiment. Physical Biology 15:056003 PDF

71. Smith S and Grima R. 2018. Single-cell variability in multicellular organisms. Nature Communications 9:345 PDF

70. Schnoerr D, Cseke B, Grima R and Sanguinetti G. 2017. Efficient low-order approximation of first-passage time distributions. Physical Review Letters 119: 210601 PDF

69. Cianci C, Schnoerr D, Piehler A and Grima R. 2017. An alternative route to the system-size expansion. Journal of Physics A: Mathematical and Theoretical 50: 395003 PDF

68. Smith S and Grima R. 2017. Model reduction for stochastic reaction systems. (published as a chapter in the Springer book: Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology DOI 10.1007/978-3-319-62627-7_7) PDF

67. Smith S, Cianci C and Grima R. 2017. Macromolecular crowding directs the motion of small molecules inside cells. J. R. Soc. Interface 14:20170047 PDF

66. Cianci C, Smith S and Grima R. 2017. Capturing Brownian dynamics with an on-lattice model of hard-sphere diffusion. Physical Review E 95:052118 PDF

65. Smith S and Grima R. 2017. Fast simulation of Brownian dynamics in a crowded environment. Journal of Chemical Physics 146:024105 PDF

64. Grima R and Leier A. 2017. Exact product formation rates for stochastic enzyme kinetics. J. Phys. Chem. B, 121:13 PDF

63. Schnoerr D, Sanguinetti G and Grima R. 2017. Approximation and inference methods for stochastic biochemical systems - a tutorial review. Journal of Physics A: Mathematical and Theoretical 50.9 (2017): 093001 PDF

62. Frohlich F, Thomas P, Kazeroonian A, Theis FJ, * Grima R and * Hasenauer J.. 2016. Inference for stochastic chemical kinetics using moment equations and system size expansion. PLoS Computational Biology 12(7):e1005030 PDF (* Joint corresponding authors)

61. Singh A and Grima R. 2016. The Linear-Noise Approximation and moment-closure approximations for stochastic chemical kinetics. (published as a chapter in a book by MIT Press) PDF

60. Voliotis M, Thomas P, Bowsher C and Grima R. 2016. The extra reaction algorithm for stochastic simulation of networks in fluctuating environments (published as a chapter in a book by MIT Press) PDF

59. Andreychenko A, Bortolussi L, Grima R, Thomas P and Wolf V. 2016. Distribution approximations for the chemical master equation: comparison of the method of moments and the system size expansion. (accepted for publication as a chapter in Springer book series) http://arxiv.org/abs/1509.09104

58. Voliotis M, Thomas P, * Grima R and * Bowsher C. 2016. Stochastic simulation of biomolecular networks in dynamic environments, PLoS Computational Biology 12(6):e1004923 PDF (* Joint corresponding authors)

57. Schnoerr D, Grima R and Sanguinetti G. 2016. Cox-process representation and inference for stochastic reaction-diffusion processes. Nature Communications 7:11729 PDF

56. Smith S, Cianci C and Grima R. 2016. Analytical approximations for spatial stochastic gene expression in single cells and tissues. J. R. Soc. Interface 13:20151051 PDF

55. Smith S and Grima R. 2016. Breakdown of the reaction-diffusion master equation with nonelementary rates. Physical Review E 93:052135 PDF

54.. Cianci C, Smith S, and Grima R. 2016. Molecular finite-size effects in stochastic models of equilibrium chemical systems. Journal of Chemical Physics 144:084101 PDF

53. Smith S, Cianci C and Grima R. 2015. Model reduction for stochastic chemical systems with abundant species. Journal of Chemical Physics 143:214105 PDF

52. Schnoerr D, Sanguinetti G and Grima R. 2015. Comparison of different moment-closure approximations for stochastic chemical kinetics. Journal of Chemical Physics 143:185101 PDF

51. Grima R. 2015. The linear-noise approximation and the chemical master equation exactly agree up to second-order moments for a class of chemical systems. Physical Review E 92: 042124 PDF

50. Thomas P and Grima R. 2015. Approximate distributions of the Master equation, Physical Review E 92:012120 PDF

49. Duncan A, Liao S, Vejchodsky T, Erban R and Grima R. 2015. Noise-induced multistability in chemical systems: Discrete vs Continuum modeling, Physical Review E 91:042111 PDF

48. Thomas P, Fleck C, Grima R and Popovic N. 2014. System size expansion of the master equation using Feynman rules and diagrams, Journal of Physics A: Mathematical and Theoretical 47:455007 PDF

47. Johansson H, Jones H. J, Foreman J, Hemsted J. R., Stewart K, Grima R and Halliday K. 2014. Arabidopsis cell expansion is controlled by a photothermal switch, Nature Communications 5:4848 PDF

46. Schnoerr D, Sanguinetti G and Grima R. 2014. Validity conditions and stability of moment closure approximations for stochastic chemical kinetics. Journal of Chemical Physics 141:084103 PDF

45. Schnoerr D, Sanguinetti G and Grima R. 2014. The complex chemical Langevin equation. Journal of Chemical Physics 141:024103 PDF

44. Middleton A, Fleck C and Grima R. 2014. A continuum approximation to an off-lattice, individual-cell based model of cell migration and adhesion. Journal of Theoretical Biology 359: 220 PDF (**Recommended reading by Faculty of 1000**)

43. Thomas P, Popovic N and Grima R. 2014. Phenotypic switching in gene regulatory networks. Proceedings of the National Academy of Sciences of the United States of America 111: 6994 PDF

42. Chew Y.H, Smith R.W, Jones H. J, Seaton D., Grima R and Halliday K. 2014. Mathematical models light up plant signaling. Plant Cell 26: 5 PDF

41. Grima R. 2014. Anomalous fluctuation scaling laws in stochastic enzyme kinetics: increase of noise strength with the mean concentration. Physical Review E. 89: 012710 PDF

40. Grima R, Nils W and Schnell S. 2014. Single molecule enzymology à la Michaelis-Menten. Febs Journal 281: 518 PDF

39. Toner DLK, and Grima R. 2013. Effects of bursty protein production on the noisy oscillatory properties of downstream pathways. Scientific Reports 3:2438 PDF

38. Thomas P, Straube A. V., Timmer J., Fleck C., Grima R. 2013. Signatures of nonlinearity in single cell noise-induced oscillations. Journal of Theoretical Biology 335:222 PDF

37. Basile R., Grima R. and Popovic N. 2013. A graph-based approach for the approximate solution of the chemical master equation. Bulletin of Mathematical Biology 75:1653 PDF

36. Thomas P, Matuschek H, Grima R. 2013. How reliable is the linear noise approximation of gene regulatory networks? BMC Genomics 14(Suppl 4):S5 PDF

35. Toner DLK, and Grima R. 2013. Molecular noise induces concentration oscillations in chemical systems with stable node steady states. Journal of Chemical Physics 138:055101 PDF

34. Grima R, and Kim J. 2012. Editorial: Modelling noise in biochemical reaction networks. 2012 IET Systems Biology 6:101 PDF

33. Ramaswamy R, Gonzalez-Segredo N, Sbalzarini IF, Grima R. 2012. Discreteness-induced concentration inversion in mesoscopic chemical systems. Nature Communications. 3:779. PDF

32. Thomas P, Matuschek H, Grima R. 2012. Computation of biochemical pathway fluctuations beyond the linear noise approximation using iNA. IEEE International Conference on Bioinformatics and Biomedicine. 10.1109/BIBM.2012.6392668 PDF

31. Thomas P, Matuschek H, Grima R. 2012. intrinsic Noise Analyzer: a software package for the exploration of stochastic biochemical kinetics using the system-size expansion. PLoS ONE. 7(6):e38518. PDF

30. Thomas P, Grima R, Straube AV. 2012. Rigorous elimination of fast stochastic variables from the linear-noise approximation using projection operators. Physical Review E. 86: 041110 PDF

29. Thomas P, Straube AV, Grima R. 2012. The slow-scale linear noise approximation: an accurate, reduced stochastic description of biochemical networks under timescale separation conditions. BMC Systems Biology. 6:39. PDF (**Editor's Pick for 2012**)

28. Wenden B, Toner DLK, Hodge SK, Grima R, Millar AJ. 2012. Spontaneous spatiotemporal waves of gene expression from biological clocks in the leaf. Proceedings of the National Academy of Sciences of the United States of America. 109:6757. PDF (**Selected as "Must Read" by Faculty of 1000**)

27. Grima R, Schmidt D, Newman TJ. 2012. Steady-state fluctuations of a genetic feedback loop: an exact solution. Journal of Chemical Physics. 137:035104. PDF

26. Grima R. 2012. A study of the accuracy of moment-closure approximations for stochastic chemical kinetics. Journal of Chemical Physics . 136:154105. PDF

25. Grima R. 2011. Construction and accuracy of partial differential equation approximations to the chemical master equation. Physical Review E. 84:056109. PDF

24. Thomas P, Straube AV, Grima R. 2011. Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks. Journal of Chemical Physics. 135:181103. PDF Supplementary PDF

23. Grima R, Thomas P, Straube AV. 2011. How accurate are the chemical Langevin and Fokker-Planck equations? Journal of Chemical Physics. 135:084103. PDF (**Editor's Choice for 2011**)

22. Grima R, Yaliraki SN, Barahona M. 2010. Crowding-induced anisotropic transport modulates reaction kinetics in nanoscale porous media. Journal of Physical Chemistry B. 114:5380. PDF

21. Grima R. 2010. An effective rate equation approach to reaction kinetics in small volumes: theory and application to biochemical reactions in nonequilibrium steady-state conditions. Journal of Chemical Physics. 133:035101 PDF

20. Grima R. 2010. Intrinsic biochemical noise in crowded intracellular conditions. Journal of Chemical Physics. 132:185102. PDF

19. Le Bihan T, Grima R, Martin S, Forster T, Le Bihan Y. 2010. Quantitative analysis of low abundance peptides in HeLa cell cytoplasm by targeted LC-MS and stable isotope dilution: Emphasizing the distinction between peptide detection and peptide identification. Rapid Communications in Mass Spectrometry. 24:1093. PDF

18. Thomas P, Straube AV, Grima R. 2010. Stochastic theory of large-scale enzyme-reaction networks: finite-copy number corrections to rate equation models. Journal of Chemical Physics. 133:195101. PDF

17. Grima R. 2009. Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments. BMC Systems Biology. 3:101. PDF

16. Grima R. 2009. Noise-induced breakdown of the Michaelis-Menten reaction in steady-state conditions. Physical Review Letters. 102:218103. PDF

15. Grima R, Schnell S. 2008. Modelling reaction kinetics inside cells. Essays in Biochemistry. 45:41. PDF

14. Grima R. 2008. Multiscale modeling of biological pattern formation. Current Topics in Developmental Biology. 81:435. PDF

13. Grima R, Yaliraki SN. 2007. Brownian motion of an asymmetrical particle in a potential field. Journal of Chemical Physics. 127:084511. PDF

12. Grima R, Schnell S. 2007. Can differential adhesion drive somite formation? Developmental Biology. 307:248. PDF

11. Grima R. 2007. Directed cell migration in the presence of obstacles. Theoretical Biology and Medical Modelling. 4:2. PDF

10. Grima R, DeGraffenreid J, Venables JA. 2007. Mean-field theory of nucleation on strained surfaces. Physical Review B. 76:233405. PDF

9. Grima R, Schnell S. 2007. A mesoscopic simulation approach for modelling intracellular reactions. Journal of Statistical Physics. 128:139. PDF

8. Schnell S, Grima R, Maini PK. 2007. Multiscale modelling in biology. American Scientist. 95:134. PDF

7. Grima R, Schnell S. 2006. How reaction kinetics with time-dependent rate coefficients differ from generalized mass action. ChemPhysChem. 7:1422. PDF

6. Grima R. 2006. Phase transitions and superuniversality in the dynamics of a self-driven particle. Physical Review E. 74:011125. PDF

5. Grima R, Schnell S. 2006. A systematic investigation of the rate laws valid in intracellular environments. Biophysical Chemistry. 124:1. PDF

4. Grima R. 2005. Strong coupling dynamics of a multi-cellular chemotactic system. Physical Review Letters. 95:128103. PDF

3. Grima R, Newman TJ. 2004. Accurate discretization of advection-diffusion equations. Physical Review E. 70:036703. PDF

2. Newman TJ, Grima R. 2004. Many-body theory of chemotactic interactions. Physical Review E. 70:051916. PDF

1. Grima R, Micallef A, Colls JJ. 2002. External contribution to urban air pollution. Environmental monitoring and assessment. 73:291. PDF